The ability of the heart to adapt to increased stress is dependent on the modification of its extracellular matrix (ECM) architecture that is established during postnatal development as cardiomyocytes differentiate, a process that is poorly understood.
Following a pregnancy, breast epithelial cells differentiate, a process that makes them more resistant to neoplastic transformation (Russo et al, 1982).
Concomitant with the loss of the mammary epithelium through apoptosis, the surrounding adipocytes differentiate, a process requiring both plasmin and MMP3 [ 5, 29].
When primary cultures of mammary epithelium from rodents or humans are cultured on solid substrata, they undergo limited replication and differentiate in a process that is regulated by hormonal factors, extracellular matrix, and cell cell interactions [ 21- 23].
Second, it suggests the need to develop theoretical models that differentiate between a process of deliberation between doctor and patient (characterized by mutual communication and empathy for the patient's feelings and values) and a final act of determining the decision to make [ 34, 35].
By analogy with petrological models for the oceanic lithosphere generated at ridges4 6, the continental lithosphere has been interpreted in terms of a comprehensive mechanical and petrogenetic unit by considering, for example, that the continental crust was differentiated through a process such as zone melting, the lithospheric mantle being the residue of this extraction process7,8.
As an alternative, embryonic stem (ES) cells can readily be differentiated in a process that correlates well with developing embryos.
Seen from the moment release curve at the decades time scale, it is also difficult to differentiate an accelerating process and a quiescence-and-recovery process.
In SSc, fibroblasts differentiate into myofibroblasts, a process characterized by excess production of αSMA.
The latter differentiate into macrophages, a process that is accompanied by increased expression of scavenger receptors, and then transform into lipid-loaded foam cells.
However, conventional distinctions among vascular cell lineages are becoming less clear as our studies and other investigators determine that ECs could also trans-differentiate into SMCs, a process known as EndMT [ 10, 11, 18, 19].
