Therefore, shared cis-regulatory elements may differentially restrict the movement of genes with particular promoter architectures or transcriptional patterns.
Hence, CTLA-4 might differentially restrict the expansion of T cells on the basis of the strength of the TCR signal they receive.
The finding that two independent afferent inputs that activate a common set of interneurons and motor neurons can be differentially conditioned restricts the possible cellular loci involved in the associative learning.
the selected 700 top ranked sets were restricted to differentially expressed genes of high statistical significance.
The group of differentially expressed genes was restricted to those genes that were detected ('present' call) in antibody-treated samples for the upregulated genes and in all control samples for the downregulated genes.
Robust statistical testing was then performed which eliminated a dependence on the normalization algorithm employed, producing a restricted list of differentially regulated genes, and which found IGF1 to be the most strongly differentially expressed gene.
In an attempt to restrict differentially expressed genes to those expressed in SM, microarray data were filtered according to the IPA knowledge-base, so that genes expressed in SM were selected.
The network analysis was restricted to genes differentially expressed between the control and the treatment groups based on previously established criteria: (1) fold change of group means ≥1.2 or ≤0.83; (2) T test p-value ≤0.05; and (3) absolute difference of group means ≥10.
In this case the statistics are restricted only to differentially expressed genes.
This analysis encompassed, but was not restricted, to the differentially expressed genes identified from both data sets, the description and analysis of which is presented below.
