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Facebook's data scientists used anonymized data to determine that "Just as certain genetic mutations can be advantageous in specific environments, meme mutations can be propagated differentially if the variant matches the subpopulation's beliefs or culture".
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Genes were considered to be expressed if RPKM > 1 and differentially expressed if log2 stress/control) > 1 or log2 stress/control) < −1.
Transcripts were considered to be differentially expressed if they differed by at least twofold and if P < 0.01.
A promoter was called differentially methylated if it contained a probe called differentially methylated and if it contained probes for which modified t-statistics were significantly higher or lower than the average probe on the microarray.
A gene was considered differentially expressed if the moderated t-test resulted in a corrected p-value <0.01.
Signals were considered differentially detected if p<0.01.
Genes were considered to be significantly differentially expressed if they obtained a p-value <0.05.
A CpG was then classified as differentially methylated if any, or both, criteria were met.
For the contrast, a gene is considered differentially expressed if the Benjamini-Hochberg-corrected P value is less than 0.05.
In the present SAM analysis, genes were considered differentially expressed if found within 20% FDR in SAM.
We scored genes as differentially expressed if they met the following criteria: a fold change >2 and a q value <5%.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com