Sentence examples for differentially establish from inspiring English sources

Our understanding of how DNA methylation and the histone code affect each other to differentially establish functional, region-specific chromatin structure is still in its early stages, but it is increasingly evident that these epigenetic marks are critical for genomic stability and disruption of these mechanisms contributes to a growing number of human malignancies.

Inherent in the understanding that there is reproducible tissue specificity in measures of methylation is the concept that methylation marks, then, must have been initially differentially established during tissue differentiation and subsequent development.

Consequently, the transendothelial (plasma vs. interstitial) concentration gradients were differentially established, such that free VEGF and sVEGFR1-VEGF complexes experienced net intravastion (IS to plasma) at control, while free sVEGFR1 had an overall tendency to extravasate (plasma to IS) at control.

This is controlled by epigenetic modifications that are differentially established on the maternal and paternal alleles in the gametes or early embryo (1, 2).

Altogether, these results suggest that the arrest of stamen development is connected to organ identity that is differentially established in ray versus disc flowers.

Using a whole transcriptome sequencing technique (RNA-Seq), we were able to identify the levels of differentially expressed genes and establish genes with alternative promoter usage and splicing patterns that changed in association with neurodegeneration.

To establish the differentially evolved genes, we next compared the phylogeny of the nine potential 'differentially evolved genes' identified above (with DNmax>0.02) with the phylogeny of the S. enetrica species and with the phylogeny of the five pathogenecity islands of Salmonella (SPI-1 to SPI-5).

The parent-specific monoallelic expression of imprinted genes is controlled by DNA methylation marks that are established differentially in the germline.

These prediction results together confirmed that the established differentially expressed proteome profile matches with the available database.

The IPA analysis revealed the top two networks of the differentially expressed genes established at either the 2 or 4 h time point after TLR3 and TLR4 stimulation in BV-2 cells.

However, imprinted genes, or parent of origin dependent monoallelic expression regulated by methylation that is established differentially on the two parental chromosomes, may play a role in many disease processes.