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To exclude a misclassification of the smoking status differential with regard to exposure, we investigated non-smoking mothers.
There is presumably a lack in registration also in this register, but probably not substantially differential with regard to breed.
We were also interested in examining whether this misclassification is differential with regard to health care utilization.
For each experiment, it was assumed that the majority of gene expression was not differential with regard to all other experiments on the same array type.
Importantly, when analysis was restricted to cases in which atrial fibrillation was the primary cause of admittance, which are less likely to be differential with regard to rheumatoid arthritis status as such cases are most often due to sudden onset of significant symptoms, the results were not affected.
Similar(55)
In general, such measurement error would attenuate the measure of association if non-differential with regard to the case status.
Furthermore, any underascertainment or competing risk for elderly patients should be non-differential with regard to occurrence of concordant cancer in the offspring.
Under the assumption that measurement error is non-differential with regard to the outcome, this might have led to biased risk estimates and reduced statistical power for detecting associations.
Although the accuracy of some characteristics may not be optimal, the variables that we used generally have high validity (Northam and Knapp, 2006) and any misclassification should be non-differential with regard to case vs control status.
Any underascertainment for elderly people, however, should be non-differential with regard to occurrence of concordant cancer in the offspring, though this could have diluted our results for those offspring whose parents were diagnosed at very advanced ages.
Because this measurement error was likely non-differential with regard to birth outcomes, the effect size estimates may be biased towards the null and, therefore, are a conservative estimate of the true magnitude of the association between cortisol and birth outcomes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com