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Because apical and basolateral membranes are only found in differentiated epithelial cells, genes critical for differential targeting may be specifically up-regulated upon MDCK cell differentiation.
Three of the miRNAs exhibiting differential targeting were themselves significantly differentially expressed; as expected, target sets had reciprocal expression to their cognate miRNAs.
Detailed attack analyses of cars from the US market could help resolve the exact role of handling costs in the differential targeting of some cars.
It is currently debated whether glucose facilitation of cognitive performance is due to differential targeting of hippocampal memory or whether task effort is a more important determinant.
To illustrate differential targeting of the FPs into specified cellular compartments, we studied and validated the expected subcellular localization of various C. guilliermondii predicted proteins fused to FPs.
The parasite-specific residues, C99, C119, and S149, represent potential sites for differential targeting, since the corresponding residues are absent in the human host's isozymes.
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We have performed two analyses to confirm that the strong differential-targeting of biological functions we observe in these networks is not a consequence of our specific approach.
Given these results, we next sought to identify if particular transcription factors might be mediating the differential-targeting of biological functions between men and women.
As with the gene in-degree analysis we once again see much stronger differential-targeting of functions in the sputum network comparison relative to the blood network comparison.
One of our most striking findings was clear differential-targeting patterns in the absence of similarly compelling differential-expression.
Across these analyses we again observe consistently strong differential-targeting of many biological functions (Additional file 1: Figure S7).
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