These data are consistent with the ability of subtype-preferring nicotinic receptor agonists to enhance specific components of working memory and cognitive function, and they suggest that differential subtype selectivity could result in varied pharmacological response profiles.
The human in vitro data showed a differential subtype pattern with pronounced levels of μ-OR and lower levels of κ-OR, but no detectable δ-OR.
In an attempt to identify the PKC subtype(s) involved in the dendrite retraction, we tested the effects of several PKC inhibitors with differential subtype specificities on the dendrite morphology.
An advance in the study of lymphoid malignancies is the development of a lymphoma classification system, the World Health Organization Classification of Lymphoid Malignancies, which recognizes the distinct molecular, morphologic, and genetic characteristics of differential lymphoma subtypes.
Even though we believe that our experimental design was appropriate to test the primary hypothesis (i.e. that the pro-angiogenic response to hypoxia would be blunted in hypertrophied hearts), the conclusion that differential VEFGR-subtype expression and activity might be the cause for this effect are based upon association and the current state of knowledge.
However, other researchers have detected subtype differences or demonstrated differential performance across subtypes when making comparisons to control groups [ 9, 10].
Proton MR spectroscopy is a non-invasive diagnostic tool that may contribute to the differential diagnosis of subtypes in ovarian tumours.
It is tempting to speculate that cell-type-specific regulation of v-rDNA represents a differential requirement of subtypes of ribosomes during development, e.g., upon maturation, mouse oocytes degrade the ribosomes not required or detrimental for embryonic development.
The CK value also serves as an important clue to facilitate the differential diagnosis of subtypes.
Seven of these BRs show a significant binding differential between the subtypes.
