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In addition, inclusion of female rhesus monkeys may reveal further insights into sex-related expression differences that have been observed for a small set of genes in developing postnatal human (4) and in adult rhesus (30), particularly in combination with differential splicing information.
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We present evidence for a putative causal mutation based on differential expression, allele specific expression and differential splicing data that created an illegitimate splice site in GBP5.
Potential candidate genes that are affected by differential splicing were identified using all information available including SI, significance, known events of alternative splicing, and transcript annotations.
Differential splicing, post-translational modifications and data integration are among some of the future challenges to tackle.
An enhanced workflow was developed to reliably detect differential splicing in an exon array data set.
Thus, additional information on transcript annotations also leads to additional identification of differential splicing events.
Differential splicing generates two isoforms, M1 or M2.
Two human ACSL4 isoforms arising from differential splicing were analyzed by ectopic expression in COS cells.
Novel SNP alleles were analyzed for potential differential splicing in vitro utilizing a splicing assay.
Dexamethasone has however, been reported to induce differential splicing in other genes [40].
Soluble forms of CD137 (sCD137) are generated by differential splicing and may limit DC activation [22], [23].
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