Importantly, YB-1 exerted different biological effects in the distinct phenotypically distinct cell subsets, separated based on their differential responsiveness to a Sox2 reporter, namely reporter responsive (RR) cells and reporter unresponsive (RU) cells [ 16].
Definition of new subgroups of patients within the endocrine non-responsive population of the CASA trial, differential responsiveness patterns to tamoxifen or to exemestane by hormone receptors and HER-2/ neu for patients in the STP trials, and the evaluation of several angiogenesis and stromal markers in the CM-Maintenance trial are ongoing or planned.
These data also demonstrate the differential responsiveness of the GH axis to appetite-regulating peptides.
Furthermore, differential responsiveness to AgNPs was observed at each developmental stage.
Thus, differential responsiveness in oxidative processes may play a major role in the differential temporal ethanol vulnerability of developing cerebellum.
Conclusions: Age-related differential responsiveness to betamethasone was found for all studied fetal processes (body and breathing movements, FHR, and quiescence), except FHR variability.
This differential responsiveness was not due to the presence of a previously described single nucleotide polymorphism at the OPRM1 gene (C77G), known to affect β-endorphin pharmacodynamics in vitro.
Our results highlight differential responsiveness of cell lines compared to primary cultured cells, and demonstrate the efficacy of the "Stealth" modification to reduce siRNA-induced interferon responses, thereby increasing target cell viability and reducing off-target effects of the delivered nucleic acids.
These findings support the concept that behavioral differences between C57 and CD-1 mice are a consequence of differential responsiveness to hypoxic insult, leading to differences in HIF-1α signaling and resulting in lower NSC proliferative/migratory and higher apoptosis rates in C57 mice.
In a recent study examining party platforms, Gerald Wright and Elizabeth Wright find, "a portion of the differential responsiveness we identified stems from parties overlooking low-income constituents who are unlikely to vote".
Nevertheless, the underlying mechanisms that govern the differential responsiveness of males and females to bacterial infection are poorly understood.
