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PATHChange is a statistical CRAN package designed to work with data downloaded from the Gene Expression Omnibus database (GEO) to determine differential pathway expression in comparative studies including control samples.
Our approach and GSEA [9] differ with regard to the following aspects: pathway scoring, differential pathway detection, and sample-specific information representation for classification.
Differential pathway regulation was assessed by a t-test with Bonferroni's correction applied and permutation testing.
This differential pathway association is especially unique, given the similarities between the receptors activated and their immediate downstream targets.
We have previously shown that distinct oncogenic mutations in EGFR deploy differential pathway utilization in cancer cells, which has therapeutic implications in the clinic [ 26, 27, 57].
In this section we evaluated how effective the PANA approach would be in studying differential pathway connectivity associated to a disease.
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"Kinetic Machine Learning Unravels Ligand-Directed CoffOpioidonal Change of Opioid Receptor" describes differential pathways of deactivation and differential conformational states sampled by the μ Opioid Receptor in response to different opioid ligands.
Given the recent debate over whether differential pathways to overt aggression and delinquency exist between boys and girls, this study examined sex differences in overt aggressive and delinquent acts along with potential differences in precursors (anger, self-control, family disruption) to antisocial behaviors among a sample of urban minority adolescents (N = 1559).
(13) Water and sodium balances are regulated through differential pathways.
These significant differential pathways could be subdivided into two major categories: one had many significant-differential components in one pathway, and the other had a few highly significant-differential components in one pathway.
Differential pathways are proposed for MeJA and SA interference, since COI1 is required only for the effect of MeJA and NPR1 only for the effect of SA.
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