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The algorithm considers two hypotheses: the observed hybridization can be explained by a differential mixture of isoforms or by a whole gene expression change, and calculates the error of both hypotheses.
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The reason for using the upper bound is that the exact differential entropy of a mixture of Gaussian functions has no analytical solution.
Interestingly, age-affected atherosclerosis signalling pathways follow the differential expression of a mixture of proteases and lipoproteins.
Due to tissue-differential and cell type-differential methylation patterns, using a mixture of multiple cell types, as routinely found in human tissues, has long been a critical hurdle in clinical studies [ 22, 23].
To demonstrate the use of our data beyond gene-level differential expression we estimated isoform expression profiles in the subtypes using the mixture-of-isoforms (MISO) model [ 49].
The discrepant results of these recent compared to earlier family studies is most likely explained by differential methodological approaches that is a mixture of probands with both bipolar-I and bipolar-II disorders, as well as the use of RDC criteria and different diagnostic measures.
Differential exposure to mixtures of environmental agents, including biological, chemical, physical, and psychosocial stressors, can contribute to increased vulnerability of human populations and ecologic systems.
In addition to selective effects within populations, differential selection on mixtures of populations with distinct characteristics can alter stock composition in fisheries.
This finding could reflect a greater cellular heterogeneity of the hippocampus compared to the striatum, as module construction can tease apart patterns of differential expression in mixtures of cell types [ 30].
The primary objective is to systematically identify the conditions for the onset of oscillations examining, in particular, the influence of differential diffusion, mixture strength, flow rate, and radiative heat losses.
In this study, we examined the peritectic mixture of lidocaine (LDC) and ibuprofen (IBP) using differential scanning calorimetry, Raman spectroscopy, and microscopy.
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