The dual role of Runx1 in regulating proliferation and differentiation could depend on differential interactions with protein partners, specific for each stage of cell development.
It remains to be established whether these differences reflect the different experimental interventions used, differences in cells examined, or differential interactions and physiologic outputs that occur during adipogenesis versus fully differentiated adipocytes.
A focus of this perspective will be on differences between yeast and mammals in the subcellular partitioning of pre-tRNA intermediates and differential interactions with La.
By exploiting the differential interactions of constituent ions with the liquid bismuth, it was possible to separate conventionally non-separable barium species from the electrolyte solution.
Additionally, cells within different parts of the tumor could experience different selective pressures before drug treatment, such as differential interactions with the extracellular matrix, gradients of oxygen, nutrition, growth factors, and blood supply.
Consequently, apparent variations in signals of tamoxifen observed in tumor and stromal cells assumed to be accounted for differential interactions with the ligands, resulting in their accumulation in spaces with higher density of target molecules, such as ER.
To design sustainable control strategies, it is necessary to have a better understanding of differential interactions that potato has developed in response to the currently pre-dominant versus the old populations of the pathogen.
Knowledge of the structure of the Ado complex in combination with a structural comparison with Homo sapiens SAHH (HsSAHH) revealed that a single substitution between the PfSAHH (Cys59) and HsSAHH (Thr60) accounts for the differential interactions with nucleoside inhibitors.
Therefore, although the crystal structure of human TS with various nucleotide ligands has not been solved, these results show that the differences observed using fluorescence methods result from as yet unidentified differential interactions between the human enzyme and nucleotide ligands.
However, it is difficult to interpret the differential interactions with DR, since both daf-2 mutations are hypomorphic, but not null, alleles [7], [17].
Therefore, factors that have differential interactions with Noggin and Follistatin are likely to be responsible for the OE derived neurite promoting activity.
