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The B-value is attained by Bayesian statistics and assigns the log posterior odds ratio of differential expression versus non-differential expression.
The "B-value" assigned to each gene is the log posterior odds ratio of differential expression versus non-differential expression [ 58, 59].
The log-odds of differential expression versus no differential expression and the moderated t-statistics were calculated by empirical Bayes shrinkage of the standard errors towards a pooled standard deviation value.
The MAANOVA tools [ 24] were chosen for their sensitivity and robustness in measuring differential expression versus previous T-test and log-ratio methods using thresholds for induction or suppression.
Similar(56)
Marker gene lists 'marker(Ai)' for each candidate subclass in A (A1.i) are determined based on the differential gene expression versus the rest of A subclasses, while genes in data set B are rank-ordered according to their correlation with each Bj subclass versus the other B subclasses to yield a gene list, 'ranking(Bj)'.
Similar comparative analyses of unaffected twins demonstrated intermediate levels of differential gene expression versus unrelated, matched controls for the majority of genes surveyed.
Among the differentially expressed coat color genes, TYRP1 showed the greatest level of differential expression in black versus white sheep skin.
Several miRNAs showed differential expression in normal versus tumour specimens: CONTIG_CHR_9, KELLY_276, MYCNAMP_NB2_5 were expressed in tumours, but not in normal tissues.
Ch3L1 showed the highest levels of differential expression in TM versus SC cells.
Genes with robust bimodal expression patterns were identified across all ovarian tumor types and also within selected subtypes: 73 bimodal genes demonstrated differential expression between LMP versus MS and EM; 22 bimodal genes distinguished MS from EM; and 14 genes had significant association with survival among MS tumors.
It is further subdivided into B-1a and B-1b subsets based on differential expression of CD5 versus Mac-1 [10].
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