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This is a working-memory paradigm based on the differential exploration of a new and familiar object.
For this purpose, the effects on memory exerted by pre-training administration of the NO synthase inhibitor L-NAME (Nω-nitro-l-arginine methyl ester) and the NO donor molsidomine (N-[ethoxycarbonyl]-3-[4-morpholinosydnomine]) were assessed by using the object recognition task, a working memory paradigm based on the differential exploration of a new and familiar object.
Another problem is that spontaneous recognition tasks use the differential exploration of novel and familiar objects to measure recognition.
On the basis of their differential exploration times, rats with perirhinal cortex lesions showed very poor discrimination of the novel objects, thereby confirming the effectiveness of the surgery.
These analyses demonstrate that both groups show differential exploration of the contexts and that their levels of exploration change during their second experience of a context.
Furthermore, as the task is based on differential exploration, the neural manipulation being tested should not have any sensorimotor effects, e.g., hyperactivity.
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This paper describes a novel optimization method based on a differential evolution (exploration) algorithm and its applications to solving non-linear programming problems containing integer and discrete variables.
The object recognition test is based on differential spontaneous exploration of novel and familiar objects (Ennaceur and Delacour, 1988).
This feature ensured the rats' continued approach to the objects, but did not affect the validity of the behavioral test of recognition as this relied on differential object exploration.
We also assessed whether different contexts had any differential effect on exploration during the habituation phase.
This arrangement motivated the rats to approach the objects, but did not affect the validity of the behavioral test of recognition, which relied on differential levels of exploration between the two baited objects.
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