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18 The model was used to simulate five different scenarios: one that does not take into consideration any therapy simplification and four that consider different LDR simplification strategies (each of the last four scenarios was compared with the "do nothing" scenario to assess the differential cost for ART).
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The best model was achieved using bagging combined with differential costs for misclassification (overall accuracy = 52.0%).
Notably, ANN and DTC model performances were comparable although differential costs for misclassification were only implemented for DTC modelling.
On the other hand, differential costs for misclassification reduced the overall accuracy of boosted decision trees from 50.8% to 49.2%.
Furthermore, as drainage classes form an ordered series rather than unrelated classes, differential costs for misclassification were tested in combination with each technique.
By far the most important direct cost factor are the so-called differential costs for the expansion of RE: the remuneration/feed-in-tariff to the investors of the RE-plants for the electricity produced (granted by the German Renewable Energies Act (GREA) for the first 20 years of operation) minus the market value of this electricity.
The differential costs for blood, medications, and surgery will be highly context specific.
The aspect of false positive PCR assays and differential costs for antimicrobial drugs was not included the cost analysis.
When considering the differential cost of HER2 tests, reagent costs for approved and laboratory-developed IVD tests used in the NordiQC laboratories were assumed at $45 and $10, respectively [NordiQC programme, personal communication].
The differential cost of comorbidities is also accounted for in some cases, as in comparing vignettes 1 and 3 but not all, as in comparing vignettes 2 and 5. CABG patients are grouped into three DRGs in the Polish system.
There are four variables in the current resource allocation formula and they are: stunting, index for differential costs of service provision, bed capacity and OPD utilization.
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CEO of Professional Science Editing for Scientists @ prosciediting.com