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There was no differential benefit for either psychological approach over the other.
Treatment effects also suggested a differential benefit for E-CMF within the first 5 years for poor prognosis tumours.
We found no evidence of a differential benefit for efficacy by IHC and RET gene copy number gains.
Throughout the trial we were encouraged that loss to follow up was comparable between groups with no strong evidence of resentful demoralisation (deliberate withdrawal of patients in the control group who perceive differential benefit for the intervention group).
26 These findings are consistent with our analyses showing more deaths from prostate cancer in those with intermediate and high risk disease (fig 1); in such men with longer life expectancies at the outset (younger men and those with fewer comorbidities) the differential benefit for surgery over radiotherapy might also be greater (fig 2).
Standard poor prognostic factors defined at diagnosis (ER negative, PR negative and HER2 positive) demonstrated their prognostic effects during the first 5 years of follow-up and the differential benefit for E-CMF in these patients may also be concentrated within the first 5 years.
Similar(53)
The current data provided no evidence for any differential benefit of vandetanib treatment based on KRAS gene mutation status, although the small number of patients with KRAS MT+ samples means that only very marked differences would have been detectable.
There was also a trend towards a differential benefit of docetaxel versus no docetaxel according to the value of Ki67 and Aurora A, with a maximum benefit for the highest quartile for both proliferation markers (Additional file 14, Table S12).
Inability to refute published claims of differential benefits of naltrexone for smoking cessation in subgroups defined by gender or secondary benefits on reduction of postcessation weight gain.
For instance, the VeriStrat serum proteomic test status was found predictive of differential benefit in terms of overall survival for non-small-cell lung cancer patients treated with second-line erlotinib versus chemotherapy [ 76].
The few variables associated with differential benefit suggest that a patient-centered supportive patient practitioner relationship may be beneficial for most patients.
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