Exact(4)
The differential background prediction is presented to eliminate the negative affect of marginal information on test vessel based on a kernel regression method.
Uninfected cells within the fields-of-view acted as internal controls to ensure that observed differences were not due to differential background staining by the antibodies (Fig. 6C).
Brain images may have differential background intensities due to both biological and technical variations; therefore, the background effect should be removed before carrying out any meaningful comparison.
Although it was expected that R2 would more appropriately account for differential background lung cancer incidence rates, and thus be a more constant ratio, its denominator – ideally an age-adjusted mesothelioma mortality rate could not be calculated – was mesothelioma proportional mortality and thus was additionally affected by differential background mortality rates.
Similar(4)
These factors suggested differential pathophysiological background of dengue patients as early as first presentation prior to ICU requirement, which may reflect the pathogenesis of dengue severity.
Prior to the analysis of differential expression, background correction and normalization procedures were performed using the LIMMA package [ 66] to remove poor quality features and standardize arrays for statistical comparisons.
This is the first systematic study, to our best knowledge, that highlighted the differential pathophysiological background of dengue patients at presentation and at 24 hours prior to ICU requirement.
This highlights differential regulatory backgrounds of both strains in the blood (see Additional file 8: Table S7).
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