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We investigated the possibility of a tyrosine kinase with differential activities in UM and UM metastasis to be responsible for ERK1/2 activation, using an array of kinase activity assays.
In particular, although our IP results suggest that FGF-2 more potently activates FGFR1 than FGFR3 in knee articular chondrocytes, we observed differential activities of FGFR1 and FGFR3 in ankle chondrocytes after FGF-2 stimulation, in which FGF-2-induced activation of FGFR3 was as potent as FGFR1 (data not shown).
The findings suggest that the left and right MTL structures may contribute differentially to the processes involved in the recognition of stimuli and that these differential activities may depend on the encoding strategies formed by the two factors of relational and self-performed processes.
Different modifications of the pendant functional groups on the scaffold provide differential activities at the opioid and NOP receptors.
Differential activities of both meristem types are crucial to the tremendous variation seen in higher plant architecture.
The differential activities of nCfEG and tCfEG were also evidenced by hydrolytic products they produced on different substrates.
To understand the mechanism for the differential activities of oximes toward AChE inhibited by diverse nerve agents in order to aid the design of new broad-spectrum AChE reactivators, we undertook site-directed mutagenesis and molecular modeling studies.
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Nevertheless, this parameter alone cannot explain the differential activity of IV (constitutively active) and V (silent), which have similar numbers of enhancer units (10 and 11).
Fig. 2 Differential activity concentration volume histograms (dAVH).
Differential activity was also seen in the posterior cingulate cortex, the fusiform, and the parahippocampic gyri.
On a lower level co-expressed genes are regulated by differential activity of transcription factors (TF).
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