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The frequency distribution of the different types of mutants and their associated selection coefficients (s, also known as fitness effects) is a key issue in population genetics (Bustamante 2005; Eyre-Walker and Keightley 2007).
The protein stability is adjusted until equation (12) is satisfied, and the relative fitness of the three different types of mutants and the corresponding acceptance rates calculated using equation (1). Figure 4 A shows the dependence of the substitution rate on the fraction and effect of the destabilizing mutations.
Second, the use of a "one size fits all" approach to mutations seems oversimplified and inaccurate, because the kinetics of accumulation of different types of mutants will depend very strongly on how and where they act, whether in cis or trans to the genome, whether they affect one protein (e.g. missense mutations) or others (nonsense mutations), etc.
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To confirm whether or not terminal bacteroid differentiation has taken place, we analyzed, by microscopy, the morphology of bacteria isolated from the different types of mutant nodules (Figure 3).
Because of their agronomic importance, the different types of dwarf mutants have been isolated from rice [ 1], Arabidopsis [ 2], and wheat [ 3].
For example, different types of Arabidopsis mutants were generated by T-DNA insertion at distinct locations in the AtPP2-A1 DNA sequence; atpp2-a1/P/-210 resulted from the insertion at nucleotide residue -210 in the promoter region.
These different types of androecium-mutant flowers were counted in ten introduced and seven native populations in the field or greenhouse.
Our study demonstrated that different types of FAD2-1A mutalleleseles bring about a similar high level of oleic acid content in the oil of soybean seeds when combined with the P137R Fallele allele from PI 283327.
The result of clonal expansion is that different cells typically contain different types of mutations, while mutant genomes within a cell carry the same mutation.
GO annotations may be assigned on the basis of several different types of evidence, including mutant phenotypes, so there can be some overlap between GO annotations and phenotype annotations.
In the existing models, crypts are usually regarded as prescribed and fixed units, and focuses of study have mainly been on dynamics of different types of cells and their mutants within single crypt.
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