Our fragment approach differs, however, in using different types of fragments, as well as by a different method to calculate fragment contributions.
Fig. 1 Definitions of different types of fragments in a molecule: a ring systems, b linkers, c side chains and d Murcko framework, e ring assemblies, f bridge assemblies, g rings, h RECAP fragments and i scaffold tree.
In contrast, incremental truncation generates two vector libraries encoding the different types of proteins fragments and screens all possible N-terminal fragments with all possible C-terminal fragments by crossing the two libraries.
They are assessing the impact of different types of forest fragments, including continuous patches of forest, so-called wildlife corridors, that allow wildlife to move in and out of plantations.
In this study, we reported the design, synthesis of the novel T-VA amide analogues containing different types of amide fragments, as well as in vitro neuroprotective activities screening on the injured PC12 cells.
In the earlier days of antibody engineering, the focus was on manipulation of the variable regions to humanize and affinity-mature antibodies, or to generate different types of antibody fragments such as scFvs (Bird et al., 1988; Huston et al., 1988), diabodies (Holliger et al., 1993), PEGylated Fabs (Choy et al., 2002), TandAbs (Kipriyanov et al., 1999), and domain antibodies (Ward et al., 1989).
The first column contains examples of three different types of DNA fragments before they are digested by MSREs.
Last, we asked if a model (M5) positing that different types of gene fragments experienced different level of adaptive substitution improved the fit of the data.
For instance, different types of matrix fragments derived from fibronectin or collagen can signal and amplify catabolic processes in chondrocytes that act to either remove tissue components for repair or to initiate reparative signals [ 3, 4].
Several different types of STB fragment are deported in normal pregnancy: larger multinucleate STB fragments, smaller uninucleate elements with CTB-like morphology, anucleate cytoplasmic fragments, microparticles and nanovesicles.
10.7554/eLife.02277.009 Figure 7. Lack of either Atl amidase or glucosaminidase activity, which leads to different types of released peptidoglycan fragments, results in decreased virulence of Staphylococcus aureus.
