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Data of Merino sheep descended from two divergent selection lines for (H line) and against (L line) multiple rearing ability were collected in three different trials to compare response to stressful situations between lines.
In order to obtain a more definitive answer, the Lung Adjuvant Cisplatin Evaluation Biomarker (LACE-Bio) collaborative group undertook a pooled analysis of KRAS mutant vs. wild type patients in four different trials to ascertain if KRAS mutational status had an effect on patients who received adjuvant chemotherapy.
In this matching procedure trials were not used more than once, but the same participant could contribute different trials to both conditions.
The primary strengths of these criteria are simplicity, reproducibility, and universal acceptance, which allow outcomes across different trials to be compared.
Meta-regression, one of the methods used, aims to relate the treatment effect recorded in the different trials to the characteristics of those trials in which the study is the unit of analysis.
Improving CVD screening is only the first step in preventing cardiovascular disease and we need different trials to determine whether identified risk factors can be reduced by specialist or general interventions for people with SMI.
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The next participant I spoke to was Paul, a Cockney spiritualist also in his mid-thirties, who was there doing a different trial to the one I and Anwar were on.
Further, results from different trials need to be comparable in order to identify most suitable vaccine candidates.
The EMA policy would in principle enable requesters to merge datasets from different trials and to generate pooled datasets.
We were surprised to find that within the past decade as much as nine different trials related to the NTI-tss device were carried out, five of which were RCTs, while four were uncontrolled investigations [ 23- 26].
A more recent analysis of the raw data from ten different trials tried to establish the relationship between the changes in 6MWD and the probability of clinical deterioration to occur [ 33].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com