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Based on the mechanisms of action, dual-targeting BsAb can be constructed to bind to different targets of the signaling pathways within the same diseased cells.
These differences do not necessarily constitute an inconsistency and could result from the different targets of the perturbations (LGN vs. apical/basal astral microtubules) and from the experimental perturbations themselves (long-term genetic ablation of LGN vs. specific and acute pharmacological down-regulation of apical/basal astrals over 24 h).
The different targets of the candidates' ad campaigns show how a race this tight could turn on any number of issues or demographics.
A better knowledge of the relevance of molecular mediators of migraine as well as their central and peripheral actions may provide clues to the development of future new drugs directed to different targets of the migraine pathophysiologic process.
Among the different targets of the Solar System, Mars is unique as the combined datasets from the Viking, Mars Global Surveyor, Mars Odyssey, Mars Express and Mars Reconnaissance Orbiter missions provide a tremendous wealth of information that can be used to study the surface of Mars.
The inversion of the t-PDC induced gamma power modulation by SNAP-5114, therefore, suggests that they are acting on different targets of the same mechanism.
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It is conceivable that the different targets of these therapies influence the different performance of Treg cells and that the results of the present study indicate a part of the unique mechanism of TCZ.
16 17 Because of the different targets of these two agents (soluble cytokine vs membrane-bound receptor), there may be differences in tolerability and spectrum of activity.
In our view, the different targets of this strategy will only be implemented if holistic approaches to research in plant conservation are effectively implemented in the near future.
However, bioinformatic prediction of its subcellular localization rather suggested a different targeting of the protein.
GnTIII: For different targeting of the human β1,4-mannosyl-β1,4- β1,4-mannosyl-β1,4- β1,4-mannosyl-β1,4-), the catalytic domain and part of the putative stem reGnTIIIcomprising amino acids 35–531) were fused thethe catalyticn of domainent enzymes.
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