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This might reflect a number of possible differences between the B. pseudomallei and E. coli hosts including differences in the levels of expression of hicA, different targets of HicA, variation in the stability of the proteins or the ability of other antitoxins present in these host cells to partially neutralize the activity of HicA.
Based on the mechanisms of action, dual-targeting BsAb can be constructed to bind to different targets of the signaling pathways within the same diseased cells.
These differences do not necessarily constitute an inconsistency and could result from the different targets of the perturbations (LGN vs. apical/basal astral microtubules) and from the experimental perturbations themselves (long-term genetic ablation of LGN vs. specific and acute pharmacological down-regulation of apical/basal astrals over 24 h).
But that leads to two very different targets of blame, and two different sets of politics," says New Yorker staff writer George Packer.
The different targets of the candidates' ad campaigns show how a race this tight could turn on any number of issues or demographics.
The different targets of EPO and IGF1 suggested their potential synergism to enhance osteogenesis.
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However, bioinformatic prediction of its subcellular localization rather suggested a different targeting of the protein.
Yvette Cooper has talked in the past of having different targets for different kinds of migration but they are not spelled out here.
In addition, the Asian fleets have very different targets from those of the Brazilian fleet.
It is, in fact, a blunderbuss blasting at a row of different targets.
In addition, the different target areas of thematic impacts would require different approaches.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com