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Fig. 2 Performance of different target classes.
In [7], a decision tree is used for a recursive classification of four different target classes.
A graphical plot is displayed in the panel showing modeled AC50 (concentration that elicits a 50% response) values for ACTIVE hit calls, which are color-coded according to different target classes (e.g. steroid hormone, nuclear receptor, GPCR, and others).
In Fig. 2a, c we plotted the BEI and LEHAC for the thermodynamic ∆G data of a series of ligands that interact with 14 different target classes, which were extracted from the BindingDB database by Reynolds and Holloway [9], respectively.
The thermodynamic ∆G data of a series of 102 protein ligand complexes that interact with 14 different target classes were assembled by gathering bioactivity information from the BindingDB database [9] by Reynolds and Holloway.
In particular, we compared the trends for the thermodynamic ∆G data of a series of ligands that interact with 14 different target classes, which were extracted from the BindingDB database with the market prices of a commercial compound library of ca. 2.5 mln synthetic building blocks.
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We selected 18 DEKOIS 2.0 datasets, each representing a different target class.
To accommodate these features, the model was fitted separately to earthquakes in three different target magnitude classes over the period 2000 2009.
To account for these features, the model was fit separately to earthquakes in three different target magnitude classes over the period 2000 2009 and made suitable to 3-month testing for M ≥ 4 and to 1-year testing for M ≥ 5.
Like in OligoRAP (3) and IMAD (4) pipelines, probes are assigned to different Target Specificity Classes (Table 1), based on the amount and type of hits (5).
The total set of all targets has been previously observed to be somewhat broadly enriched for regulatory/signaling proteins [ 26], and some of the categories become more pronounced when analyzing the different constitutive and alternative target classes separately.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com