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In this paper, the different steps of development and experimental validation of a new type of three-dimensional (3-D) trapezoidal osteosynthesis plate (Modus TCP® 2.0, Medartis, Basel, Switzerland) is described.
Russel and McCluggage [ 25] and also Kurman and Shih [ 21] proposed a new theory that distinguishes between high grade and low grade serous carcinoma and tries to reconstruct the different steps of development in those entities.
Wild-type C57Bl/6 mice homozygous for a spontaneous albino mutation were sacrificed at three different steps of development, the day of birth (P0), postnatal day 5 (P5) and at the age of 4 weeks.
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In parallel with genetics approaches, efforts have been made to screen mutant libraries for lines presenting alterations in root development, allowing for the identification of several genes that control different steps of root development, such as crown root and lateral root initiation and emergence, meristem patterning, and the control of root growth.
Our focus was to identify different steps of osteophyte development via analysis of expression patterns of marker genes of chondrocytic differentiation.
The first one identifies the generic components of an embedded system while the second one details how to model and validate the embedded system throughout the different steps of the development process.
In addition, it must be considered that identity genes act within a hierarchically structured network of interactions and at different steps of muscle development.
Many of the targets encode transcription factors or signalling proteins controlling different steps of plant development.
This multi-step nature of metastatic cascades suggests that divergence between oligometastases and polymetastases may be initiated on different steps of metastases development.
More recently, Kiontke et al. (Kiontke et al. 2007) examined 51 rhabditid species and identified variations in different steps of vulva development.
In this manuscript we discuss what a guideline is, where we can find guidelines, how to evaluate the quality of guidelines, and finally provide an example on the different steps of guideline development.
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