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TGF-b may be present in the skin under three forms, each representing a different state of activation and each performing a distinct function with regards to TGF-b signalling in skin cells.
The discrepancies in results between studies may reflect difference between species (humans, rats and mice) or some experimental condition such as different strains of animals or animal models, different state of activation of the immune cells or classes of cells and in some cases, limited number of subunits being examined.
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Similarly, INs exhibits two different states of activation w.r.t.
ENs exhibit three different states of activation with respect to (w.r.t). to sonar, timer, camera, and transceiver as shown in Table 1.
There is also a growing awareness that there is considerable heterogeneity of phenotype and function within the macrophage population and that a greater understanding of these different states of activation may result in the development of therapies specifically designed to capitalize on this variation in phenotype and cellular responses.
Comparing the two protocols allowed us to discriminate between effects of membrane potential noise riding on top of the EPSP and the effects of having ion channels in different states of activation at the time of input arrival.
Macrophages are plastic cells characterised by different states of activation.
It is likely that different subsets of immune cells, and different states of activation are in part responsible for these discrepancies.
This does not exclude the possibility that our Bregs could in fact be a heterogeneous population consisting of memory and transitional B cells in different states of activation.
MSC within a primary culture can also exhibit different states of activation which can be related to the expression levels of certain micro RNAs (miR) including miR335 [ 132].
The authors state that functional analysis of proliferation may provide a better tool for identification of specific monocyte subsets since it is difficult to know if specific patterns of surface marker expression represent different states of activation or differentiation.
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