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There are a variety of different CRLs, each associating with a specific cullin protein and possessing different specificity, depending on the adaptor and/or substrate-specifying subunit used (Petroski and Deshaies 2005).
Downregulation of VRK1 induced by p53 is prevented in a dose dependent manner by either p300 or CBP, but not by PCAF, used as transcriptional co-activators, suggesting that p53 has a different specificity depending on the relative level of these transcriptional cofactors.
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Human MC receptors-expressing COS-7 cells bind BE with different specificities depending on the MC subtype.
Residue 102 mutations frequently result in different levels of substrate specificity, depending on which protein they are made in.
Changing the threshold in model A, we can vary sensitivity and specificity depending on needs.
MGLs have been identified throughout all genera of life and have adopted different substrate specificities depending on their physiological role.
BACE1 cleaves APP at two different sites, the β-site or β'-site, to produce C99 and C89, respectively, and the regulation of β-cleavage site specificity depends on the subcellular localization of BACE1.
Better understanding of this specificity depends on modelling studies based on ample structural and biochemical information.
However, the overall change in specificity depended on the target compound.
This specificity depends on the creation of intracellular microdomains containing signaling molecules tethered on scaffolding molecules.
The ultimate diagnostic sensitivity and specificity depend on the choice of cutoff.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com