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To obtain an unbiased estimate of the generalization error of the different sets of modules, we used a double-loop cross validation procedure [17].
Different sets of modules, or the same set of modules with distinct conditional connectivity, can respond differently to the same changes in cell state, allowing each biomolecule to build unique regulatory programs (Fig. 3c d).
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The goals and scale of a particular study may require a completely different set of modules that will be invoked and further translated into a working model.
Although the repeated trials seeking solutions found a different set of modules in each of the trials, each complete module in the most frequent solution was detected with high reproducibility: 74.5% of the 10,000 trials for module 1, 70.3% of the trials for module 2, 98.2% of the trials for module 3, and 97.9% of the trials for module 4 (Additional file 4e-h).
Different strains encode different sets of effector modules, yet outside these modules, retain conserved genes of the T6SS, including genes encoding structural and regulatory components and an ATPase.
The central KanMX4 module can be used in multiple deletion cassettes in combination with different sets of flanking modules.
These modules are designed on the base of mathematical models of vehicle separate elements and different physical effects, such as flexibility, sloshing, sluggishness of engines, local angle of attack values, etc. Selection of different sets of program modules allows investigating different designs for known and prospective vehicle.
Then, the division of the sperm head into three different sets of morphological modules was tested.
We propose that these different sets of signalling modules are central components of the apical growth mechanism.
The structure suggests a simple mechanism for DNA break processing, explains how AddAB and RecBCD can accomplish the same overall reaction with different sets of functional modules and reveals details of the role of an Fe S cluster in protein stability and DNA binding.
As we ran the PPA with different sets of thresholds, redundant modules were obtained.
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