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The different responsiveness of the three MADA cell cultures to drug treatments is shown in Fig. 2b and c.
This probably results in different responsiveness of the gustatory nerves to different taste qualities (e.g., Ninomiya 1998; Inoue et al. 2001; Danilova and Hellekant 2003).
A standard dose (i.e., 1 mg overnight) unequivocally resulted in normal inhibition of cortisol secretion in obese individuals with different phenotypes, 58 whereas low doses (i.e., ≤0.5 mg or less overnight) have been suggested to provide potential insights into the different responsiveness of the HPA axis and obesity (in both sexes).
(2) For functional positional candidate genes being under trans control it can be speculated that the nature of variation affecting the phenotype is differential expression due to polymorphisms in hierarchically superior genes and different responsiveness of the candidate genes to regulatory mechanisms.
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The different responsiveness of one of the 12-h piglets, however, obliged us to interpret our overall results carefully, especially, concerning the five genes that reacted solely at 12 hpi (TXN, FRK, DppC-2, IF144, and ACTB; see Table 2).
The molecular reasons of the different responsiveness of certain endothelial cell types to the stilbenes need also to be precisely delineated.
What is the molecular basis of the different responsiveness of TNFRSF receptors toward binding of soluble TNFSF ligands?
These data have to be further investigated to understand if patients have to be stratified, taking into account in which gene (BRCA1 or BRCA2) they carry a deleterious mutation, which would then allow us to assess the reason for the different responsiveness of BRCA1 and BRCA2 mutation carriers to PARP inhibitors.
The different responsiveness of androgen-sensitive and -insensitive cells could be explained by our findings obtained in experiments in which we investigated regulation of the AR signaling pathway by sorafenib.
Thus, instead of different intrinsic responsiveness of the target genes to morphogen (Driever et al., 1989; Jiang et al., 1991), the regulatory logic of the transcriptional circuit determines the pattern of expression of each gene.
The effect is characterised by a programming of the genome that leads to different responsiveness and adaptability of the gene expression machinery to chronic and acute environmental stimuli, i.e. nutritional supply.
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