Cancer is the result of the accumulation of genetic and epigenetic alterations, which in turn means there are different profiles of gene expression in various lung cancers [ 1].
Both STAT5 variants seem to have a persistent effect, probably on chromatin structure and accessibility [ 16, 48, 49], which results in different profiles of gene expression in the developing tumors.
If resistance can be associated with, for example, ten different profiles of gene expression, we can expect only a few trees for each strategy to be present in our sampling.
The great diversity of cells found in animals is a consequence of different cell types expressing different profiles of genes during cell fate determination and differentiation.
Remarkably, a quite different profile of ABC gene expression was observed in PCa stratified according to the TMPRSS2-ERG transcript status.
The most highly represented contigs in each age group (0.1% of transcript pool; 79, 111 and 107 contigs for 0 4, 8, and 12-16dpp, rexhibitedly) exhibited markedly different profiles of putative gene function.
Might pannocytes have a different profile of chemokines and tumor suppressor genes?
We identified 34 genomic clusters using aCGH data; several genes exhibited a different profile of aberrations between AC and SCC, including PIK3CA, SOX2, THPO, TP63, PDGFB genes.
Notwithstanding the ubiquitous selected genes across the Sahel, there were different profiles of candidate selected genes in the Western and Eastern sides.
However, it is possible to identify subclusters of genes with moderately different profiles of expression within the three main networks (Additional file 5).
