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The different patterns of amplification we observed suggest complex amplification mechanisms leading to a variety of subtypes.
On the basis of the alignment between the two genomes, different patterns of amplification were expected from the genomes of M. ap K-10 and M. ap ATCC 19698.
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Hierarchical clustering of DNA copy number profiles separated the samples into two groups, with visual inspection of the heatmap showing that cores taken from the same tissue block often demonstrated very different patterns of amplifications and deletions.
Clone E8 showed a different pattern of amplification involving almost the entire 8p chromosome arm.
The hAT, Tc1/Mariner, and Helitron superfamilies show different pattern of amplification, yet they are predominantly represented by young families, whereas divergent families are exceedingly rare.
HER2 amplification seems to drive genomic instability along chromosome 17q, leading to different patterns of gene amplification.
HER2+/ER- and HER2+/ER+ presented different patterns of anomalies; in particular, loss at 5q was limited to ER- and amplification at 11q13 was limited to ER+.
But different patterns of colonization have created divergent worlds.
Different locations have different patterns, of course.
The third class of profile, detected in 4 cases, revealed the coexistence of 19q loss with different patterns of gains/amplifications (Figure 3D).
This is different from the pattern of amplification that we observed for ARQ/VRQ scrapie sources as shown in Table 1.
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CEO of Professional Science Editing for Scientists @ prosciediting.com