Although the pathogen is similar, clinical features carry significant differences across different patient subgroups.
Moreover, data are not provided that show whether differences exist between different patient (subgroups) nor what the effect of medication is.
In order to determine how differences in screening compliance in different patient subgroups affected the cost-effectiveness, we performed a subgroup analysis.
Given the emerging belief that FM may be an umbrella diagnosis for multiple different subtypes of patients suffering from whole-body pain, differences in brain alterations between different patient subgroups may help explain symptom heterogeneity.
Secondly, as the sample size was small, differences in repeatability of measurements in different patient subgroups could not be assessed.
In order to understand to which extent gene promoter methylation is relevant to NB, we analyzed differences in the methylation levels among different patient subgroups.
Specifically, we applied unsupervised hierarchical clustering on the GSE2990 dataset to cluster cancer patients into subgroups based on the expression pattern of the 17 modules, and then investigated difference in relapse-free survival for different patient subgroups by comparing their survival curves estimated using the Kaplan-Meier method.
We can see what is likely to benefit different patient subgroups, to finally address the needs of all, which will mean that a drug that is effective for some people but not for most will not have to be denied to those it can help.
The mean hospitalisation period, calculated in nights per patient per year, was 4.1 (median 2.5 nights, SD 4.6 nights) and was similar between the different patient subgroups.
Moreover, no significant difference in the genotypic or allelic frequencies was found: (i) when control group was compared to different patient subgroups stratified by diagnosis; (ii) between PTB and EPTB subgroups (iii) between SevTB and LNTB subgroups (Table 3).
The specificity of urine LAM and smear microscopy, using the non-TB group as a reference, in the different patient subgroups is shown in Figure 2. In summary, LAM was highly specific (95 to 100%) in all subgroups but specificity was comparatively lowest in the CD4<200 cells/mm3 subgroup (but not statistically different from other subgroups).
