Reasons for this apparent difference in uptake rate from different pathways are unclear.
Mutational analysis of the EcR LBD) revealed that ligand entry and exit is affected differently by the same point mutation, indicating that different pathways are used for association and dissociation of the ligand.
It is amazing that a single miRNA promotes both stages as different pathways are required to be shut down during the early and later stages of reprogramming.
Inherent in the latter model is that if the waters in the different pathways are collected and mixed, the "dispersion length" is proportional to distance.
Since several different pathways are involved in cerebral ischemia/reperfusion injury, combination therapy rather than monotherapy may be required for efficient neuroprotection.
We find also, in agreement with the theoretical predictions, that different pathways are controlled by different time scales and, thus, exhibit different sensitivity to restriction.
Different pathways are evaluated and ranked according to different objective functions to understand the best combination of products and the synergies between them.
These different pathways are under direct control of several miRNAs.
These different pathways are modeled collectively as pseudo-first-order reactions with aggregate rate constants (Figure 7 and Table 1).
One class of molecules that seem to have access to many of these different pathways are the GPI-anchored proteins (GPI-APs).
Nevertheless, the presence of phosphorylated nuclear β-catenin indicates that different pathways are operational downstream of TCR signalling compared to Wnt signalling.
