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These had isolated over a two week period (24 April to 8 May 2007) from 11 different neonates; Table 1.
However, Fig. 1 also shows that the 30 E. coli isolates only formed five pulsotypes, and therefore multiple indistinguishable strains had been isolated from different neonates over a one year period.
Three strains (786, 780, 796) from feeding tube biofilms belonged to PT4 and were isolated over a one month period (16 January to 16 February 2007) from 2 different neonates fed breast milk, fortified breast milk, and reconstituted infant formula.
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In a different neonate with the R1623Q SCN5A mutation, mexiletine was initially effective in controlling QT prolongation, but it was difficult to maintain a therapeutic concentration, possibly due to poor absorption from the gastrointestinal track[24].
In addition to the potential risk for increased bleeding in the neonatal population, the efficacy of recombinant human-activated protein C may also be different in neonates due to underlying developmental differences in the coagulation pathway.
Propofol disposition is significantly different in neonates compared with toddlers and young children, reflecting both ontogeny and differences in body composition.
Our data suggest that JVO2 and AVDO2 are different in neonates and pediatric patients.
The safety profile of TPM might be different in neonates with HIE treated with hypothermia than in adults receiving chronic therapy for epilepsy.
The main finding of this trial was that overall outcomes were not significantly different for neonates receiving shorter- versus longer-duration antibiotics.
The elimination half-life of intravenous fosphenytoin was not significantly different between neonates (<29 days), infants (2 days to <2 years), children (2 to <12 years), and adolescents (12 to <17 years).
Because the only subjects aged <29 days were 5 subjects with pH1N1 virus infection, and normal laboratory values are different in neonates compared with other age groups, we excluded all subjects aged <29 days from the assessment of laboratory results.
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