Sentence examples for different mutations of the from inspiring English sources

Finally, it remains to be assessed whether different mutations of the same gene result in similar phenotypes, or whether differences in amounts and activity of the synthesized protein, if present, might result in different patterns of auditory nerve discharge.

More than 100 different mutations of the transthyretin gene were identified worldwide, but still the first described Val30Met is the most common one.

Many researchers assume that similarities among organisms in very different environments would occur by evolution of different genes, or at least different mutations of the same genes.

The problem was that there are 1,800 different mutations of the CFTR gene; get any one from each parent and a person will have CF. Most of these prevent CFTR proteins from even getting to the surface of a cell.

A report by Reardon et al. (2001) of a nine-year-old boy exhibiting facial, caudal and urogenital anomalies consistent with Malpuech syndrome, who also had skeletal malformites indicative of Juberg-Hayward suggests, suggesthathathehe two disorders may be allelic (caused by different mutations of the same gene).

The above procedure allows for the derivation of the functional consequences of different mutations of the system: Unlike wild type, the R mutant (R = 0, Table 3) reaches a premature differentiation level early at about 40 50 pfh.

This gene is responsible for the last step in cholesterol synthesis, and its inhibition results in hypocholesterolemia and accumulation of 7-dehidrocholesterol [35], while different mutations of this gene cause the Smith-Lemli-Opitz syndrome [36].

These findings underscore the correlation between the polymerization and trafficking defects of the different mutations of neuroserpin and the severity of the clinical phenotype of FENIB.

Alternatively, viral vectors could be used in the Fxn-knockout background to test the effect of the different mutations on the function of a specific tissue.

A number of studies have investigated the influence of different mutations on the autoactivation process [ 6- 8].

There, we described how the evaluation is influenced when different mutations of proteins from the training set are used for testing.