Sentence examples for different modes of target from inspiring English sources
Such differences in DNA methylation sensitivity are likely due to their different modes of target recognition: the 5-methyl group on C does not affect proper base pairing with gRNA, but might abolish the protein:DNA interaction in the major groove for ZFNs and TALENs.
Alternately, some of these miRNAs may have different modes of target recognition [ 16].
Bartel (2009) discusses different modes of canonical target recognition: 7mer-A1 sites, 7mer-m8 sites (our seed classification), and 8mer sites.
Because they each have a very different mode-of-action in target plants, these two herbicides are often applied in rotation in agricultural cropping systems.
One limitation to the comparison is that all high-throughput genetic screens for modifiers were performed in different model organisms and used very different screen set-ups, including different modes of gene targeting and scoring for different phenotypes (Table 2).
Different cell types seem to have different modes of STAT6-mediated target activation.
NSAIDs and fluoroquinolone are structurally unrelated molecules, have completely different modes of action and target functionally unrelated proteins.
Drugs with different modes-of-action, potencies, and potential for off-target effects may have dissimilar effects on gene expression under these reported experimental conditions.
The nonlinear material behaviour of GFRP has been modeled employing shock effect for studying the different modes of failure in the target.
Another example are de-methylation inhibitors (DMI fungicides, FRAC group G1) that are designed to interfere with cytochrome P450 monooxygenases in target fungi but can affect diverse and different biochemical pathways in various species and thereby display different modes of actions in non-target organisms [27].
Using the Raf/MEK/ERK signalling pathway as paradigm, we have highlighted some of these mechanisms including differential protein interactions, subcellular compartmentalisation, different modes of activation, and differential targeting of downstream effectors.
