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We interpret these differences as reflections of different modes of regulation of these miRNAs in the two model species.
In the following sections, we examine the evolutionary histories of regulatory genes in each of these three categories separately to determine if LGT has affected these different modes of regulation differently.
This difference is crucial for the significantly different modes of regulation and function among DAP kinases.
Our results suggest that each class may be subject to different modes of regulation or interact with differently constituted basal transcription complexes, and demonstrate that the genome has a complex organizational structure at the promoter level.
It is clear that a substantial proportion of the individual gene components of TRNs have been subject to LGT within the E. coli - Shigella clade, and that different modes of regulation are impacted by LGT differently.
Our finding that a variant Mig1 site, GTGGGG(A/G/T)(A/T G, is significantly enriched in redundantly repressed promoters, but absent from promoters repressed only by Mig1, suggests that differences in sequence specificity between Mig1 and Mig2 may account for different modes of regulation.
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Such prominent differences indicate that these splice variants might have different mode of regulation and different functional properties.
An English lecture calls for a different mode of regulation than a practical lesson in surgery.
This observation could result from a different mode of regulation of these subunits, at least in the mentioned tissues.
Thus, although in both species complete methylation of CpGs in the promoters characterizes inactive alleles, the number of CpGs involved is different suggesting a different mode of regulation by DNA methylation.
Detailed promoter analysis of these genes did not identify a classical ISRE motif, implying a different mode of regulation.
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