Three different methods for measurement of insulin concentrations were used in both DGI and PPP-Botnia: RIA (Pharmacia), enzyme linked immunoassay (DAKO Diagnostics Ltd ,Cambridgeshire, UK) and fluoroimmunoassay (Delphia, Perkin-Elmer Finland, Turku, Finland).
The agreement levels for the different methods for SBP measurements are shown in Table 2. Agreement between methods was highly variable, from a CCC of 0.35 (95% CI 0.05, 0.59) for baseline pre-dialysis and standardized methods to a CCC of 0.94 (95% CI 0.89, 0.97) for cumulative intra-dialysis and cumulative post-dialysis methods.
There have been debates regarding TL measurements as to whether different methods for TL measurement could affect the informativeness of TL measures for genetic and epidemiological studies involving TL [19], [20], [21].
Genotype based assays are cheap, have high fidelity, and can be multiplexed, in contrast to multiple phenotypic risk factors and biomarkers, many of which require different methods for their measurement, and which are more affected by biological variability and measurement error than is genotyping.
There are different methods for structural measurement, such as gradient modulus (GM), Harris response, etc.
Use of different methods for the measurement of diabetes and the demographic structure of Phoenix may have affected our findings.
Pesticides were not included as a group in Table 2 because they are not chemically similar and therefore require different methods for exposure measurement.
A total of three different methods for lactate measurement (enzymatic: n = 19, automatic analyzer: n = 2, gas-liquid chromatography n = 2) were performed in the 25 included studies.
Findings from numerous studies show remarkable consistency across ethnically and racially diverse study populations despite the use of many different methods for ANA measurement.
Reasons for this include the use of different methods of measurements for HbA1c and varying reference ranges for the non-diabetic population.
