One of the primary reasons for this is that out core gene set was defined solely from colon cancer cells which are physiologically distinct from both bladder and breast cancers and may employ different mechanisms of gene expression regulation.
In this chapter, we first describe different mechanisms of misregulated gene expression resulting in various pathophysiological conditions.
Our analysis suggests that the several arms of gene regulatory network modulate the expression of the SLC6A3, whereby differential engagements and/or combinatorial interplay of different mechanisms of this network, DAT expression can be robust and reliable yet plastic and adjustable to accommodate environmental demands.
Two functional subsets of Foxp3+ Treg cells with distinct capacity to secrete IL-10 and TGF-β and using different mechanisms of suppression were defined by expression of ICOS [24].
Acquired resistance to pralatrexate was associated with decreased RFC-1 expression, whereas methotrexate resistance correlated with increased DHFR expression, suggesting different mechanisms of acquired resistance.
Out of the different mechanisms of insect resistance to Bt toxins, expression of high gut proteases is one major mechanism s, which leads to degradation of Bt toxins.
In summary, the analytical methodology utilized in our study provides an excellent approach to integrate and understand the complex regulatory network of B. subtilis, a network that modulates the expression of the different mechanisms of adaptation and cell differentiation that this bacterium has evolved in response to the environmental changes that it must constantly face.
The divergent co-expression pattern suggests different mechanisms of BMP signaling in human and mouse ESCs, a result consistent with experimental data.
Accordingly, this may indicate a different mechanism of regulation of mHtt expression.
The increased activity of the cathepsins could arise from several different mechanisms, including increased expression of the protein, decreased expression of endogenous protein inhibitors or enhanced conversion of inactive proenzymes into their mature active forms.
