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To test this hypothesis, the effects of the adenosine-A1 agonist capadenoson on the NE release in vitro as well as on heart rate in vivo was evaluated in two rat strains with genetically different levels of sympathetic activity, Wistar and Spontaneously Hypertensive rats (SHR).
The findings emphasize the role of the sympathetic nervous system in regulating hypertension and suggest different levels of sympathetic activation in HT patients compared with NT patients [ 49, 50].
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These findings indicate different levels of psychological stress and sympathetic tone in the two patient groups, and the oxygen tension in the group that received only the less-effective opioid analgesia was so low that it predisposed to surgical wound infection.
The physiological relevance of our in vitro observations was confirmed by quantification of sympathetic innervation density of tissues that express different levels of NGF.
With a growing understanding of bi-directional interactions between the sympathetic and parasympathetic efferent pathways at different levels of the neuraxis and at target organs [ 2], it is possible that autonomic imbalance may be shown to be a key component involved in both the aetiology and the clinical course of cardiovascular disease.
To assess the physiological relevance of our in vitro findings, we studied the sympathetic innervation of several tissues that express markedly different levels of NGF.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com