With regard to the specific diagnoses within the medical conditions under study, the most common cause of HF was ischaemic heart disease (34.9%), and 78.6% of patients with CLD had COPD with different levels of severity: moderate (17.4%), severe (21.7%) and very severe (60.9%).
The primary outcome was the efficacy of probiotic yogurt in prevention of diarrhoea, classified at different levels of severity: for example, less severe (stool frequency ≥2/day for 2 or more days with stool consistency ≥5 on the BSS); more severe (stool frequency ≥3/day for 2 or more days with stool consistency ≥6 on the BSS).
Spreading defects for these 10 genes as well as a number of controls, genes previously implicated in mesoderm migration (i.e., htl AB42, pyr e02915/BSC25, and pyr /BSC25), were scored and quantified into the different levels of severity: normal, mild, moderate, or severe.
If a patient reported episodes of hypoglycaemia at different levels of severity, the patient was classified according to the most severe episode reported.
Depressive symptoms were measured by the Major Depression Inventory and the impact of different levels of depressive symptoms (severe, moderately severe, moderate, mild and none) and changes in depressive symptoms (worsened, improved, unaffected) on early retirement intentions were analysed with multinomial logistic regression.
Blalock et al. analysed samples from 35 patients with four different levels of AD severity: control, incipient, moderate and severe; for this paper we used only 31 samples for which information is available online.
One of the reasons for using this classification is that different levels of injury severity can be clearly defined (e.g., from skin contusion to severe liver laceration).
Macias and colleagues asked whether the response to therapeutic interventions could be influenced by different levels of disease severity, including the suggestion that biological manipulation may be beneficial in the most severe patients and harmful in the less severe patients.
