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Different levels and duration of hypoxia cause varying adverse effects from time to time.
To date, HypoxiaDB is the first study that lists tissue-specific protein expression changes under different levels and duration of hypoxia.
HypoxiaDB is distinctive from other generalized databases: (i) it compiles tissue-specific protein expression changes under different levels and duration of hypoxia.
NanoString analysis allowed precise comparisons of transcript levels in response to different levels and duration of Nodal exposure (Geiss et al., 2008; Strobl-Mazzulla et al., 2010; Nam and Davidson, 2012).
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Directional differences in reported effects may stem from different levels and durations of exposure, and may explain the positive association with T3 observed here among Akwesasne adolescents.
Moreover, the molecular response in each tissue varies under different levels and durations of hypoxia.
Different levels and durations of elevated IOP can be obtained by altering the frequency and number of microspheres injected [ 47].
Both these databases do not provide tissue-specific expression profile of the protein under different levels and durations of hypoxia.
Hence, this section contains tissue-specific expression pattern changes of the protein under different levels and durations of hypoxia compiled from various publications.
HypoxiaDB uniquely provides the tissue-wise expression pattern of the proteins in different levels and durations of hypoxia (Supplementary Figure S1F).
It is a comprehensive, manually-curated, non-redundant catalog of proteins whose expressions are shown experimentally to be altered at different levels and durations of hypoxia.
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