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These sorts of differences would lead to very different understandings of the relative contributions of different kinds of mutations and inferences about the molecular mechanisms involved.
The patients were selected in order to cover different kinds of mutations distributed over multiple genes.
For example, in leukemias, IDH1 can bear different kinds of mutations, but almost always at amino acid position 132.
Different kinds of mutations have been described such as missense/nonsense, small or gross deletion, splicing, insertions and duplications [ 2].
This study provides valuable data on the different kinds of mutations occurring at various target loci in resistant MTBC strains isolated from samples obtained from the Eastern Cape Province.
Reviewer 1 "Since most of the mutations are harmful... ........ First table brings to mind that different kinds of mutations exist: punctual deletion recombination (leading to gene loss end exon shuffling...)...
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FMTS implements different kinds of mutation operators that describe common FM faults from diverse categories.
Different kinds of G6PD mutations may result in variable severity of clinical onset in G6PD-deficient individuals.
SW480, HT29 and HCT116 cells harbor different kinds of oncogenic mutations which reflect the common spectrum of alterations in colorectal cancers [ 15].
In an important study analyzing 1794 breast cancer patients, the stratification of different kinds of TP53 mutations showed that all loss-of-function p53 mutants correlated with poor prognosis compared with wt p53 cases (17).
While this result must be interpreted with caution because it is based on few data points, it is interesting that it holds for many different kinds of resistance mutation, including those that confer resistance through both small molecule efflux and target binding.
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