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We anticipate that pain will be measured in various ways, and thus different instruments will be applied to monitor the changes during any given trial period.
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These and many other questions imply that different types of monitor instruments will be needed for different categories of diseases.
As already shown in Fig. 1, it is envisaged that PRO-AE instruments will be used to collect different datasets at different stages of drug development.
But removing the instruments will be expensive.
Since treatment in the intervention arm is based on the outcomes of this new instrument, which is based on the CCQ, a different quality-of-life instrument will be used to measure the primary outcome.
One instrument, the Mini-RF radar instrument, will be ended.
The instrument will be validated.
A smaller instrument will be more convenient.
Clearly, application of these different instruments will lead to different conclusions given this degree of variability.
"Within different countries, there will be different choices of instruments - such as taxes, trading and standards - and different technological mixes.
Weak instrument scenarios will be common in multivariable Mendelian randomization, as it is necessary to use multiple instrumental variables to estimate the different causal effects.
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