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İşeri, Ö. D., Kars, M. D. & Gündüz, U. Two different docetaxel resistant MCF-7 sublines exhibited different gene expression pattern.
Gardner and his team are continuing to delve into their databanks, now asking if the microbiome, epigenetics or a different gene expression pattern can clue them in to why there's such drastic variability between dieting individuals.
More importantly, this gene expression profile was preserved in response to oxidative stress in co-cultured CMs while single cultured CMs showed a significantly different gene expression pattern under stress, suggesting a stabilizing effect of iECs on CMs under oxidative stress conditions.
Hypertonic fluid administration resulted in a different gene expression pattern compared with isotonic fluid.
ISGs are marked with an asterisk Open image in new window Figure 2 Different gene expression pattern triggered by type I and type III IFNs.
Spheroids obtained from HepG2 cells also show a markedly different gene expression pattern compared to monolayers.
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Mutations affect each human calvarial suture (coronal, sagittal, metopic, and lambdoid) differently, suggesting different gene expression patterns exist in each human suture.
Note that the fact that gene regulatory mechanisms have evolved already demonstrates that different environments require different gene expression patterns, that is, expressing a gene at the 'wrong' level for a given environment has negative effects on fitness/growth rate.
Undoubtedly such phenotypic differences will be as a result of different gene expression patterns, although strain-specific differences have been relatively under investigated in this species with the majority of research being focused on a single laboratory-adapted line.
A selection of genes chosen in order to illustrate the different gene expression patterns among the 130 differentially expressed genes at all absorbed doses studied.
These two are associated with distinctly different gene expression patterns and more importantly, a significant difference in clinical outcome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com