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Disability will be measured using the 12-item version of the WHO Disability Assessment Schedule 2.0 (WHODAS 2.0), consisting of 6 different functioning domains: cognition (2 items), mobility (2 items), self-care (2 items), getting along (2 items), life activities (2 items), and participation (2 items) [ 38 ].
Difference in stability, relative stability, degrees of controllability, and transient responses between normal and abnormal cells means considerable difference in dynamical behaviours and different functioning of cells.
Measurement invariance ensures that differences can be ascribed to differences between groups that are not due to different functioning of the measure per se (for details on estimating measurement invariance in the present study, see Additional file 1).
The difference in NAD+ production may explain the different functioning of SIRT1 in articular chondrocytes and IVD cells.
These huge differences displayed by the two networks implied different functioning modes according to the tumor [ER] status and suggested that there could be a quantifiable link between ERα36 position into the network and/or its expression level and tumor metastatic progression.
Mean differences should reflect actual group differences in the underlying attribute and should not reflect a different functioning of the measures across the different groups.
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