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Building on this topological classification scheme, recent functional connectivity studies [22] have suggested that brain regions with high centrality may either link to other regions within a more local neighborhood (i.e. likely forming a single functional cluster) or interconnect to regions over longer distances (i.e. likely members of different functional clusters).
Subsequent clustering identified at least three different functional clusters.
Note that individual genes may be annotated within several different functional clusters.
To examine the different functional clusters in these two phases, categories of the GO database were analyzed.
For exploring superfamily diversity in the CATH-Gene3D resource, we have used an approach that searches for SDPs to distinguish between different functional clusters [ 22].
To determine whether the enriched TCs of different tissues contained different functional clusters, we analyzed the EST populations of lung, cerebellum, and retina that are in the GO database.
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I found that different functional gene clusters have different spatial distributions of TFBSs, indicating that gene regulation mechanisms may be very different among different functional gene clusters.
I found that different functional gene clusters have different spatial distributions of the TFBSs.
In summary, my results show that different functional gene clusters have different spatial distributions of the TFBSs, indicating that gene regulation mechanisms may be very different among different functional gene clusters.
Moreover, I used my method to construct the spatial distributions of the TFBSs for different functional gene clusters.
These clusters contain proteins in different functional classes; one cluster in VZV contains proteins involved in virion assembly, nucleotide repair, metabolism, and host-virus interaction.
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CEO of Professional Science Editing for Scientists @ prosciediting.com