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Both radiation and chemotherapy can also lead to causing future cancers different from the targeted cancer (Source 2).
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Moreover, vaccination may result in directional selection favoring AMA-1 alleles that are different from those targeted by the vaccine, resulting in reduced efficacy over time.
We thus knocked down CREB3L1 by transiently transfecting cells with two distinct siRNA targeting CREB3L1 at regions different from that targeted by the shRNA.
We also generated SK-N-SH clones stably expressing a shRNA directed against a vimentin mRNA sequence different from that targeted by the siRNAs.
To rule out the off-target effects of the shRNA, we also transfected Huh7 cells with two distinct siRNA targeting regions of CREB3L1 that is different from that targeted by the shRNA.
The epitope is different from that targeted by all other anti-EGFR therapies and is not accessible in normal human tissues (Jungbluth et al, 2003).
Such programs are different from those targeting the general population as sexual orientation and risks need to be considered.
By this method, the median entropy of total Gag (1000 Gag, 0.25) or Pol (1000 Pol, 0.16) was not significantly different from the epitopes targeted in these gene products (p > 0.05 and p ≥ 0.5 for all comparisons, respectively; Fig. 2C).
Dunnet's test showed that collectively the syringes were significantly different from the target.
Such probes, about 20 nucleotides long, sometimes bind loosely to sequences slightly different from the target sequence.
The latter have the composition usually different from the target composition while the composition of the former is very close to the target (master alloy) composition.
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