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"It's quite different from nearest neighbor technologies, and opens up new possibilities for neuroscientists," Ting said.
LBVS results with 3DXfp and 3DAPfp were themselves different from nearest neighbors retrieved using the 2D-fingerprints Xfp and APfp.
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Haematological interactions (haemolysis and plasma coagulation times) of positively charged nanoparticles were considerably different from near-neutral and negative nanoparticles.
The chromosomal region around D. aromatica's two nosZ homologs is notably different from near-neighbors A. aromaticum EbN1 and Ralstonia solanacearum which encode a nosRZDFYL cluster.
Both 3DXfp and 3DAPfp gave very different nearest neighbors from different diastereomers, which were also different from the nearest neighbours obtained by the parent 2D-fingerprint search with Xfp or APfp, highlighting the impact of stereochemistry on LBVS.
Precipitation in the Sydney Basin is isotopically different from the nearest GNIP sites with a significantly higher D-excess.
However some of the chimpanzee kinases are radically different from the nearest human kinases (Table 2).
Protocols were modified from MRC-Holland (www.MRC-Holland.com), and probe pairs were designed to differentiate paralogs by including a minimum of five nucleotides different from their nearest match.
Rainbowfish are evolutionarily very different from their nearest genome-enabled species, Oryzias latipes, yet in this study we were able to generate a substantial list of candidate genes involved in a response to increasing temperatures.
These are patients 25 and 30 (patients P and Q) in Figure 4 A. Analysis of the genetic relatedness of all MRSA t032 study isolates demonstrated that whereas patient P/25's isolate was 96 SNVs different from its nearest neighbor, the isolate from patient Q/30 was genetically indistinguishable (0 SNVs) from that carried by patient M, who was discharged 7 weeks earlier.
If there were means outside this range the procedure is repeated with comparisons with the second highest and so on until the lowest (highest) value is included in a nonsignificant range or it is declared significantly different from the nearest mean.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com