However, the concept of functional impairment is complex, involving different domains of functioning and areas of life.
A second advantage of the EORTC QLQ-HCC18 is that it provides subscale scores for different domains of functioning.
There is considerable debate about how to best assess physical functioning and physical performance, and a recognition that different measures map to different domains of functioning.
In this sense the current data add support to the idea that ADHD is a disorder with distinct cognitive and behavioural elements which will probably affect different domains of functioning in different ways.
The questionnaires used for this survey contained the SRGH question as well as questions about the extent of problems in different domains of functioning, with and without assistive devices or personal assistance.
Frailty is characterized by a decline in reserve capacity in different domains of functioning, resulting in a decline in mobility, unintended weight loss, an elevated risk of morbidity, an increase in depression and anxiety, institutionalization, and premature death [ 1, 2].
Because frailty is characterized by a decline in reserve capacity in different domains of functioning, we may consider a person to be frail if he or she obtains a GFI sum score of at least 4 points and reports problems in at least two domains of frailty.
Future research could use more sensitive and targeted measures of functioning, including scales that require direct observation of actual or role-played functioning, to assess different domains of functional outcomes.
In regard to developmental methylmercury exposure, we have previously discussed that the temporal windows of susceptibility may differ between different domains of brain function [ 23].
There were no significant differences between the effects of lead within the different domains of executive function.
